NO-H2S interactions involve cGMP

نویسندگان

چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

PDE5 says NO to cGMP

A protease inhibitor unsticks cells AI-1 is unique among protease inhibitors because it binds to the matrix protein vitronectin (VN). PAI-1 binding blocks VN's binding site for the cell surface receptor uPAR and for integrin family members. Czekay et al. (page 781) now show that PAI-1 is also able to detach cells through a less direct approach. Unlike the direct competition method, PAI-1 also d...

متن کامل

NO/cGMP signalling in platelets

Background NO/cGMP-signalling is important for the inhibition of platelet aggregation. The cGMP dependent protein kinase I plays thereby the key role in the signal cascade of NO/ cGMP. It is already known that the interaction of the cGKI substrate IRAG with the IP3RI is essential for the NO/ cGMP dependent inhibition of platelet aggregation. To specify the relevance of IRAG signalling for plate...

متن کامل

Sperm whale predator-prey interactions involve chasing and buzzing, but no acoustic stunning

The sperm whale carries a hypertrophied nose that generates powerful clicks for long-range echolocation. However, it remains a conundrum how this bizarrely shaped apex predator catches its prey. Several hypotheses have been advanced to propose both active and passive means to acquire prey, including acoustic debilitation of prey with very powerful clicks. Here we test these hypotheses by using ...

متن کامل

Complex interactions of NO/cGMP/PKG systems on Ca signaling in afferent arteriolar vascular smooth muscle

Fellner SK, Arendshorst WJ. Complex interactions of NO/cGMP/ PKG systems on Ca signaling in afferent arteriolar vascular smooth muscle. Am J Physiol Heart Circ Physiol 298: H144–H151, 2010. First published October 30, 2009; doi:10.1152/ajpheart.00485.2009.—Little is known about the effects of nitric oxide (NO) and the cyclic GMP (cGMP)/protein kinase G (PKG) system on Ca signaling in vascular s...

متن کامل

Complex interactions of NO/cGMP/PKG systems on Ca2+ signaling in afferent arteriolar vascular smooth muscle.

Little is known about the effects of nitric oxide (NO) and the cyclic GMP (cGMP)/protein kinase G (PKG) system on Ca(2+) signaling in vascular smooth muscle cells (VSMC) of resistance vessels in general and afferent arterioles in particular. We tested the hypotheses that cGMP-, Ca(2+)-dependent big potassium channels (BK(Ca(2+))) buffer the Ca(2+) response to depolarization by high extracellula...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: BMC Pharmacology and Toxicology

سال: 2013

ISSN: 2050-6511

DOI: 10.1186/2050-6511-14-s1-o32